Meet the Founder

Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study

M. Rewers, D. Agardh, S. Bennett Johnson, E. Bonifacio, H. Elding Larsson, P. Gesualdo, W. Hagopian, M.J. Haller, H. Hyoty, R. Johnson, R. McIndoe, E. McKinney, J. Melin, A. Lernmark, R.E. Lloyd, K.F. Lynch, J.M. Norris, S.S. Rich, R. Roth, D. Schatz, J. Toppari, E. Triplett, K. Vehik, S.M. Virtanen, A.G. Ziegler, B. Akolkar, J.P. Krischer, TEDDY Study Group

Diabetes Care (2025) · DOI

The BinDiscover database: a biology-focused meta-analysis tool for 156,000 GC-TOF MS metabolome samples

P.L. Bremer, G. Wohlgemuth, O. Fiehn

Journal of Cheminformatics (2023) · DOI

Denoising Autoencoder Normalization for Large-Scale Untargeted Metabolomics by Gas Chromatography-Mass Spectrometry

Y. Zhang, S. Fan, G. Wohlgemuth, O. Fiehn

Metabolites (2023) · DOI

Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study

G. Miao, Y. Zhang, Z. Huo, W. Zeng, J. Zhu, J.G. Umans, G. Wohlgemuth, D. Pedrosa, B. DeFelice, S.A. Cole, A.M. Fretts, E.T. Lee, B.V. Howard, O. Fiehn, J. Zhao

Diabetes Care (2021) · DOI

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study

Q. Li, H. Parikh, M.D. Butterworth, A. Lernmark, W. Hagopian, M. Rewers, J.X. She, J. Toppari, A.G. Ziegler, B. Akolkar, O. Fiehn, S. Fan, J.P. Krischer, TEDDY Study Group

Diabetes (2020) · DOI

Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS

T. Intararuchikul, N. Teerapattarakan, R. Rodsiri, M. Tantisira, G. Wohlgemuth, O. Fiehn, R. Tansawat

Biomedical Chromatography (2019) · DOI

A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium

D.K. Barupal, Y. Zhang, T. Shen, S. Fan, B.S. Roberts, P. Fitzgerald, B. Wancewicz, L. Valdiviez, G. Wohlgemuth, G. Byram, Y.Y. Choy, B. Haffner, M.R. Showalter, A. Vaniya, C.S. Bloszies, J.S. Folz, T. Kind, A.M. Flenniken, C. McKerlie, L.M.J. Nutter, K.C. Lloyd, O. Fiehn

Metabolites (2019) · DOI

Metabolite-related dietary patterns and the development of islet autoimmunity

R.K. Johnson, L. Vanderlinden, B.C. DeFelice, K. Kechris, U. Uusitalo, O. Fiehn, M. Sontag, T. Crume, A. Beyerlein, A. Lernmark, J. Toppari, A.G. Ziegler, J.X. She, W. Hagopian, M. Rewers, B. Akolkar, J. Krischer, S.M. Virtanen, J.M. Norris, TEDDY Study Group

Scientific Reports (2019) · DOI

Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics

Z. Lai, H. Tsugawa, G. Wohlgemuth, S. Mehta, M. Mueller, Y. Zheng, A. Ogiwara, J. Meissen, M. Showalter, K. Takeuchi, T. Kind, P. Beal, M. Arita, O. Fiehn

Nature Methods (2018) · DOI

Identification of small molecules using accurate mass MS/MS search

T. Kind, H. Tsugawa, T. Cajka, Y. Ma, Z. Lai, S.S. Mehta, G. Wohlgemuth, D.K. Barupal, M.R. Showalter, M. Arita, O. Fiehn

Mass Spectrometry Reviews (2018) · DOI

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

M. Rewers, H. Hyoty, A. Lernmark, W. Hagopian, J.X. She, D. Schatz, A.G. Ziegler, J. Toppari, B. Akolkar, J. Krischer, TEDDY Study Group

Current Diabetes Reports (2018) · DOI

SPLASH, a hashed identifier for mass spectra

G. Wohlgemuth, S.S. Mehta, R.F. Mejia, S. Neumann, D. Pedrosa, T. Pluskal, E.L. Schymanski, E.L. Willighagen, M. Wilson, D.S. Wishart, M. Arita, P.C. Dorrestein, N. Bandeira, M. Wang, T. Schulze, R.M. Salek, C. Steinbeck, V.C. Nainala, R. Mistrik, T. Nishioka, O. Fiehn

Nature Biotechnology (2016) · DOI

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing

B. Lernmark, K. Lynch, J. Baxter, R. Roth, T. Simell, L. Smith, U. Swartling, S.B. Johnson, TEDDY Study Group

Journal of Diabetes Research (2016) · DOI

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study

U. Uusitalo, X. Liu, J. Yang, C.A. Aronsson, S. Hummel, M. Butterworth, A. Lernmark, M. Rewers, W. Hagopian, J.X. She, O. Simell, J. Toppari, A.G. Ziegler, B. Akolkar, J. Krischer, J.M. Norris, S.M. Virtanen, TEDDY Study Group

JAMA Pediatrics (2016) · DOI

Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry

S. Miyamoto, S.L. Taylor, D.K. Barupal, A. Taguchi, G. Wohlgemuth, W.R. Wikoff, K.Y. Yoneda, D.R. Gandara, S.M. Hanash, K. Kim, O. Fiehn

Metabolites (2015) · DOI

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY

M. Lonnrot, K. Lynch, H.E. Larsson, A. Lernmark, M. Rewers, W. Hagopian, J.X. She, O. Simell, A.G. Ziegler, B. Akolkar, J. Krischer, H. Hyoty, TEDDY Study Group

BMC Pediatrics (2015) · DOI

Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes

K.M. Kemppainen, A.N. Ardissone, A.G. Davis-Richardson, J.R. Fagen, K.A. Gano, L.G. Leon-Novelo, K. Vehik, G. Casella, O. Simell, A.G. Ziegler, M.J. Rewers, A. Lernmark, W. Hagopian, J.X. She, J.P. Krischer, B. Akolkar, D.A. Schatz, M.A. Atkinson, E.W. Triplett, TEDDY Study Group

Diabetes Care (2015) · DOI

Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)

A.K. Steck, K. Vehik, E. Bonifacio, A. Lernmark, A.G. Ziegler, W.A. Hagopian, J. She, O. Simell, B. Akolkar, J. Krischer, D. Schatz, M.J. Rewers, TEDDY Study Group

Diabetes Care (2015) · DOI

Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study

C. Torn, D. Hadley, H.S. Lee, W. Hagopian, A. Lernmark, O. Simell, M. Rewers, A. Ziegler, D. Schatz, B. Akolkar, S. Onengut-Gumuscu, W.M. Chen, J. Toppari, J. Mykkanen, J. Ilonen, S.S. Rich, J.X. She, A.K. Steck, J. Krischer, TEDDY Study Group

Diabetes (2015) · DOI

Risk of pediatric celiac disease according to HLA haplotype and country

E. Liu, H.S. Lee, C.A. Aronsson, W.A. Hagopian, S. Koletzko, M.J. Rewers, G.S. Eisenbarth, P.J. Bingley, E. Bonifacio, V. Simell, D. Agardh, TEDDY Study Group

New England Journal of Medicine (2014) · DOI

Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease

H. Elding Larsson, K. Vehik, P. Gesualdo, B. Akolkar, W. Hagopian, J. Krischer, A. Lernmark, M. Rewers, O. Simell, J.X. She, A. Ziegler, M.J. Haller, TEDDY Study Group

Pediatric Diabetes (2014) · DOI

Prevalence of obesity was related to HLA-DQ in 2-to-4-year-old children at genetic risk for type 1 diabetes

J. Yang, A. Lernmark, U.M. Uusitalo, K.F. Lynch, R. Veijola, C. Winkler, H.E. Larsson, M. Rewers, J.X. She, A.G. Ziegler, O.G. Simell, W.A. Hagopian, B. Akolkar, J.P. Krischer, K. Vehik, TEDDY Study Group

International Journal of Obesity (2014) · DOI

Iron-dependent modifications of the flower transcriptome, proteome, metabolome, and hormonal content in an Arabidopsis ferritin mutant

D. Sudre, E. Gutierrez-Carbonell, G. Lattanzio, R. Rellan-Alvarez, F. Gaymard, G. Wohlgemuth, O. Fiehn, A. Alvarez-Fernandez, A.M. Zamarreno, E. Bacaicoa, D. Duy, J.M. Garcia-Mina, J. Abadia, K. Philippar, A.F. Lopez-Millan, J.F. Briat

Journal of Experimental Botany (2013) · DOI

Sample preparation for metabolomics of Saccharomyces cerevisiae

S. Kim, D.Y. Lee, G. Wohlgemuth, H.S. Park, O. Fiehn, K.H. Kim

Analytical Chemistry (2013) · DOI

Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function"

S.M. Quanbeck, L. Brachova, A.A. Campbell, X. Guan, A. Perera, K. He, S.Y. Rhee, P. Bais, J.A. Dickerson, P. Dixon, G. Wohlgemuth, O. Fiehn, L. Barkan, I. Lange, B.M. Lange, I. Lee, D. Cortes, C. Salazar, J. Shuman, V. Shulaev, D.V. Huhman, L.W. Sumner, M.R. Roth, R. Welti, H. Ilarslan, E.S. Wurtele, B.J. Nikolau

Frontiers in Plant Science (2012) · DOI

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue -- a GC-TOFMS based metabolomics study

J. Budczies, C. Denkert, B.M. Mueller, S.F. Brockmoeller, F. Klauschen, B. Gyorffy, M. Dietel, C. Richter-Ehrenstein, U. Marten, R.M. Salek, J.L. Griffin, M. Hilvo, M. Oresic, G. Wohlgemuth, O. Fiehn

BMC Genomics (2012) · DOI

MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity

D.K. Barupal, P.K. Haldiya, G. Wohlgemuth, T. Kind, S.L. Kothari, K.E. Pinkerton, O. Fiehn

BMC Bioinformatics (2012) · DOI

BinBase mass spectral database for compound identification in untargeted metabolomics

K. Skogerson, G. Wohlgemuth, D.K. Barupal, O. Fiehn

BMC Bioinformatics (2011) · DOI

Metabolite profile changes in xylem sap and leaf extracts of strategy I plants in response to iron deficiency and resupply

R. Rellan-Alvarez, H. El-Jendoubi, G. Wohlgemuth, A. Abadia, O. Fiehn, J. Abadia, A. Alvarez-Fernandez

Frontiers in Plant Science (2011) · DOI

Global metabolite profiling of agarose degradation by Saccharophagus degradans 2-40

M.H. Shin, D.Y. Lee, G. Wohlgemuth, I.G. Choi, O. Fiehn, K.H. Kim

New Biotechnology (2010) · DOI

Global metabolic profiling of plant cell wall polysaccharide degradation by Saccharophagus degradans

M.H. Shin, D.Y. Lee, K. Skogerson, G. Wohlgemuth, I.G. Choi, O. Fiehn, K.H. Kim

Biotechnology and Bioengineering (2010) · DOI

The Chemical Translation Service -- a web-based tool to improve standardization of metabolomic reports

G. Wohlgemuth, P.K. Haldiya, E. Willighagen, T. Kind, O. Fiehn

Bioinformatics (2010) · DOI

Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria

E.L. Seifert, O. Fiehn, V. Bezaire, D.R. Bickel, G. Wohlgemuth, S.H. Adams, M.E. Harper

PLoS ONE (2010) · DOI

Changes in the proteomic and metabolic profiles of Beta vulgaris root tips in response to iron deficiency and resupply

R. Rellan-Alvarez, S. Andaluz, J. Rodriguez-Celma, G. Wohlgemuth, G. Zocchi, A. Alvarez-Fernandez, O. Fiehn, A.F. Lopez-Millan, J. Abadia

BMC Plant Biology (2010) · DOI

Analysis of early host responses for asymptomatic disease detection and management of specialty crops

A.M. Dandekar, F. Martinelli, C.E. Davis, A. Bhushan, W. Zhao, O. Fiehn, K. Skogerson, G. Wohlgemuth, R. D'Souza, S. Roy, R.L. Reagan, D. Lin, R. Cary, P. Pardington, G. Gupta

Critical Reviews in Immunology (2010) · DOI

PlantMetabolomics.org: a web portal for plant metabolomics experiments

P. Bais, S.M. Moon, K. He, R. Leitao, K. Dreher, T. Walk, Y. Sucaet, L. Barkan, G. Wohlgemuth, M.R. Roth, E.S. Wurtele, P. Dixon, O. Fiehn, B.M. Lange, V. Shulaev, L.W. Sumner, R. Welti, B.J. Nikolau, S.Y. Rhee, J.A. Dickerson

Plant Physiology (2010) · DOI

Metabolomic and transcriptomic analysis of the rice response to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae

T.R. Sana, S. Fischer, G. Wohlgemuth, A. Katrekar, K.H. Jung, P.C. Ronald, O. Fiehn

Metabolomics (2010) · DOI

FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry

T. Kind, G. Wohlgemuth, D.Y. Lee, Y. Lu, M. Palazoglu, S. Shahbaz, O. Fiehn

Analytical Chemistry (2009) · DOI

Comparison of gas chromatography-coupled time-of-flight mass spectrometry and 1H nuclear magnetic resonance spectroscopy metabolite identification in white wines from a sensory study investigating wine body

K. Skogerson, R. Runnebaum, G. Wohlgemuth, J. de Ropp, H. Heymann, O. Fiehn

Journal of Agricultural and Food Chemistry (2009) · DOI

Metabolite profiling of human colon carcinoma -- deregulation of TCA cycle and amino acid turnover

C. Denkert, J. Budczies, W. Weichert, G. Wohlgemuth, M. Scholz, T. Kind, S. Niesporek, A. Noske, A. Buckendahl, M. Dietel, O. Fiehn

Molecular Cancer (2008) · DOI

Quality control for plant metabolomics: reporting MSI-compliant studies

O. Fiehn, G. Wohlgemuth, M. Scholz, T. Kind, D.Y. Lee, Y. Lu, S. Moon, B. Nikolau

The Plant Journal (2008) · DOI

Setup and Annotation of Metabolomic Experiments by Integrating Biological and Mass Spectrometric Metadata

G. Wohlgemuth, O. Fiehn

Lecture Notes in Bioinformatics (2005) · DOI